Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
eMolecules 76045-93-7 | 2,2,2-Trifluoroacetic acid- 2-bromoethyl ester | Oakwood Chemical | MFCD28396350 | 220.973 | C4H4BrF3O2 | 98.000 | FC(F)(F)C(=O)OCCBr | 1g | 537706582
2,2,2-Trifluoroacetic acid- 2-bromoethyl ester | Oakwood Chemical | 76045-93-7 | MFCD28396350 | 220.973 | C4H4BrF3O2 | 98.000 | FC(F)(F)C(=O)OCCBr | 1g | 537706582
Medchemexpress LLC MtvkPabc-p5 TFA | 1190.22 | C54H74F3N11O16 | 5 MG
MTvkPABC-P5 TFA is a Toll-like receptor 7 (TLR7) agonist and immune stimulant used as a reagent for synthesizing immune-stimulating antibody conjugates (ISACs). It is supplied as the trifluoroacetic acid (TFA) salt in solid form. Molecular formula: C54H74F3N11O16; molecular weight: 1190.22.
- Acts as a TLR7 agonist and immune stimulant.
- Used to synthesize immune-stimulating antibody conjugates (ISACs).
- Supplied as the trifluoroacetic acid (TFA) salt in solid form.
- Storage: solid -20°C; protect from light; store under nitrogen.
- Available pack sizes: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg.
Medchemexpress LLC Ncgc00138783 tfa | 896700-07-5 | 99.4% | C28H27F4N7O3S | 1 MG
Ncgc00138783 TFA is a selective inhibitor targeting the CD47/SIRPα axis, with an IC50 of 50 μM. It directly blocks the interaction between the CD47 and SIRPα axis.
- Target: CD47/SIRPα axis
- Selective inhibitor
- Blocks CD47/SIRPα interaction
- Molecular weight: 617.62
- Appearance: Solid, white to light yellow
- Purity: 99.4%
- Applications in immunology/inflammation
![Medchemexpress LLC Carbamic acid, N-methyl-N-[2-(methylamino)ethyl] ester, 2,2,2-trifluoroacetate | 1224601-17-5 | MFCD01938808 | 98.1% | 620.57 g/mol | C29H31F3N4O8 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000201969.png-250.jpg)
Medchemexpress LLC Carbamic acid, N-methyl-N-[2-(methylamino)ethyl] ester, 2,2,2-trifluoroacetate | 1224601-17-5 | MFCD01938808 | 98.1% | 620.57 g/mol | C29H31F3N4O8 | 1 ML
SN-38-CO-DMEDA TFA is a research-grade carbamate intermediate (trifluoroacetate salt) used in the synthesis of antibody-drug conjugates such as LND1035. Supplied as a 10 mM solution in DMSO (1 mL), it has CAS number 1224601-17-5, chemical formula C29H31F3N4O8, molecular weight 620.57 g/mol, and reported purity 98.07%.
- 10 mM solution in DMSO, 1 mL
- Intended for use as a chemical synthesis intermediate
- Reported purity 98.07%
- CAS number 1224601-17-5
- Available as solid quantities in multiple sizes
Medchemexpress LLC Mtvkpabc-p5 TFA | 98.8% | 1190.22 | C54H74F3N11O16 | 25 MG
MTvkPABC-P5 TFA is the trifluoroacetic acid (TFA) salt of a synthetic Toll-like receptor 7 (TLR7) agonist. It functions as an immune stimulant used in research applications, including the synthesis of immune-stimulating antibody conjugates (ISACs).
- Acts as a TLR7 agonist and immune stimulant.
- Suitable for synthesis of immune-stimulating antibody conjugates (ISACs).
- Provided as a solid TFA salt.
- High purity, 98.8%.
- Molecular weight 1190.22, formula C54H74F3N11O16.
- Available as 25 MG quantity.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic Acid | CAS 76-05-1
Trifluoroacetic Acid | Purity: >=99.0% | M. W.: 114.02 | 76-05-1 | 200-929-3
Medchemexpress LLC AS-99 TFA | 99.1% | C29H31F6N5O5S2 | 1 MG
AS-99 TFA is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor (IC50 of 0.79 μM, Kd of 0.89 μM) with anti-leukemic activity. It functions by blocking cell proliferation, inducing apoptosis and differentiation, downregulating MLL fusion target genes, and reducing the leukemia burden in vivo.
- Potent and selective ASH1L histone methyltransferase inhibitor
- Demonstrates anti-leukemic activity
- Blocks cell proliferation
- Induces apoptosis and differentiation
- Downregulates MLL fusion target genes
- Reduces leukemia burden in vivo
- Exhibits over 100-fold selectivity towards ASH1L over 20 other histone methyltransferases
- Suppresses MLL fusion driven transcriptional programs
- Leads to dose-dependent downregulation of canonical MLL fusion target genes
TARGETMOL CHEMICALS INC LEVOROTATION NIMORAZOLE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Levorotation nimorazole phosphate ester TFA is an anti-anaerobic and anti-parasitic agent.
![eMolecules 1810069-99-8 | bis(2,2,2-trifluoroacetic acid);2-(2,2,2-trifluoroethyl)-2,6-diazaspiro[3.3]heptane | MFCD29037458 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502158414.JPG-250.jpg)
eMolecules 1810069-99-8 | bis(2,2,2-trifluoroacetic acid);2-(2,2,2-trifluoroethyl)-2,6-diazaspiro[3.3]heptane | MFCD29037458 | 1g
Medchem Express | Azosemide | 10mg | 495799592 | HY-107321 | 27589-33-9 | MFCD00867321 | 370.830 | C12H11ClN6O2S2
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Medchemexpress LLC JPS014 TFA | 98.12% | C48H60F3N7O9S | 25 MG
JPS014 TFA is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC). It degrades class I histone deacetylase (HDAC) and is a potent HDAC1/2 degrader. This degradation correlates with a greater number of total differentially expressed genes and enhanced apoptosis in HCT116 cells.
- Benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC)
- Degrades class I histone deacetylase (HDAC)
- Potent HDAC1/2 degrader
- Correlates with greater total differentially expressed genes
- Enhances apoptosis in HCT116 cells
Medchemexpress LLC 7-TFA-ap-7-Deaza-dA | 178420-75-2 | 98.8% | 399.32 | 1 ML
7-TFA-ap-7-Deaza-dA is a modified nucleoside that can be used in the synthesis of deoxyribonucleic acid or nucleic acid. It functions as a click chemistry reagent, containing an alkyne group that undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Modified nucleoside.
- Can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
- Functions as a click chemistry reagent.
- Contains an alkyne group for reactions.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups.
Medchemexpress LLC 2H-Cho-Arg (TFA) | 1609010-59-4 | 99% | 886.06 | 1 MG
2H-Cho-Arg (TFA) is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.
- Steroid-based cationic lipid
- Contains a 2H-cholesterol skeleton
- Coupled to an L-arginine head group
- Facilitates gene transfection
- Stable under recommended storage conditions
- For research use only
Medchemexpress LLC CL2A (TFA) | 2616704-22-2 | 99.5% | 1176.24 | C50H79N9O16 | 5 MG
CL2A (TFA) is a pH-sensitive, cleavable PEG8- and triazole-containing PABC-peptide-mc linker for use in antibody-drug conjugate construction. The TFA salt form improves handling and stability and is designed to release payloads under acidic conditions to produce a bystander effect.
- Cleavable linker enabling payload release under acidic conditions.
- PEG8 spacer and triazole moiety for increased solubility and stability.
- Designed for conjugation to antibody cysteine residues via disulfide linkage.
- Available in small research-scale packages for use in ADC development.
- Stable as a powder when stored sealed at 4°C; shipped at room temperature.
Medchemexpress LLC JPS016 (TFA) | 99.5% | C50H64F3N7O10S | 1 MG
JPS016 (TFA) | 99.5% | C50H64F3N7O10S | 1 MG
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 4 x 2 mL
Trifluoroacetic acid | Purity: 99% | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 | 4 x 2 mL